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In C57BL/6 mice, an unrestricted KD with 13E% from protein reduced tumor growth after transplantation of Lewis lung carcinoma cells compared with a high-CHO diet (77E% CHO), and this became significant when protein was further restricted to 5E% and replaced with fat

This leads to severe gut dysregulation, which is worse in aged animals [26,27,28]

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Several mediators of apoptosis, pyroptosis, and necroptosis have been proposed to contribute to progressive neurodegeneration in experimental MS models [3,4,5,6,7,8], arguing for the involvement of multiple regulated cell death modalities (RCD) in this complex and heterogeneous pathology