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In this context, the increased extracellular glutamate can bind to its receptor, the metabotropic glutamate receptor 5 (mGluR5) on the stellate cell surface, stimulating it to synthesize 2-arachidonoylglycerol (2-AG) [155], which in turn, once released into the extracellular space, binds to the cannabinoid receptor-1 (CB1R) on hepatocytes, triggering a mechanism of de novo lipogenesis and therefore of fat accumulation [156] (Figure 7)

Induction of Peroxiredoxins in Transplanted Livers and Demonstration of Their In Vitro Cytoprotection Activity

Consistent with this notion, under conditions of cysteine starvation, the GSH-catabolizing enzyme CHAC1 mobilizes cysteine to sustain mitochondrial Fe-S cluster biogenesis and respiratory function

This can be achieved by incorporating whole grains, legumes, fruits, and plenty of vegetables into your meals