As expected, exposure to HnB mainstream led to a significant induction of CYP1A1, including protein expression, CYP2B1/2 (activating olefins and halogenated hydrocarbons) and CYP2A1/2 (activating, polychlorinated biphenyls, aromatic amines, PAHs, and alkylnitrosamines)
In turn, this inhibition leads to suppression of the production of inflammatory cytokines such as IL-6, TNF and IL-8 as shown for various immune cells in vitro , in animal immune models and in immune-compromised human (129131)
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