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Resistance to azoles is increasingly reported and involves several mechanisms: Overexpression of efflux pumps, including members of the ABC transporter superfamily and major facilitator superfamily (MFS)

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One example is when politicians and commentators point out the role of DARPA funding in the development of the Internet

Elevated IGF-1 activity has been associated with tumor cell proliferation and, epidemiologically, with certain cancer risks, which is why IGF-1R has been pursued as a target for inhibition in oncology