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Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells

Figure 4 The catalytic domains of G6PD5.4 and G6PD5.5 face the cytosol and are functional Membrane topology at the ER can be analyzed by taking advantage of differences in redox state between the ER lumen (largely oxidized) compared to the cytosol (largely reduced)