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Patients may begin to see measurable improvements in hair density around 3 months, with visible cosmetic improvement between 46 months

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In diabetic brains, these cytokines prompt the synthesis of ROS and trigger various cellular pathways such as advanced glycation end products (AGE), and protein kinase C (PKC) to cause neuroinflammation and neurodegeneration and ultimately CD (Zilliox et al., 2016)

Because vitamin (especially folate) supplementation can efficiently reduce plasma homocysteine levels, further prospective cohort studies and ongoing, randomized, placebo-controlled trials will determine the efficiency of folate supplementation, possibly in combination with vitamins B 12 and B 6 , in the prevention and correction of vascular disorders related to moderate hyperhomocysteinemia