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Importantly, these implications were observed without direct immunosuppression of specific cytokines such as TNF, implying a more regulatory mode of action

You may want to talk with a doctor about B12 shots if you regularly experience: Persistent fatigue and lethargy Muscle aches and joint pain Loss of appetite Nausea, constipation, diarrhea, or cramping Poor memory or difficulty concentrating Mood swings Can B12 Injections Help With Mood Enhancement and Mental Clarity

If you are taking high-dose supplements, your GP might recommend reducing to a maintenance dose once deficiency is corrected

The receptor is specific to the IF-B 12 complex, and so will not bind to any vitamin content that is not bound to IF