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L.OxleyA

El-Nablaway et al., 2024)

Aims This review aims to synthesize the mechanisms underlying SC s actions in NCD prevention and management, clarify its therapeutic and preventive roles across clinical populations and suboptimal health states, and explore its applications within the framework of predictive, preventive, and personalized medicine (PPPM/3PM)

Due to the poor predictive value of animal models for human responses to drugs, the cross-correlations between the in vitro human BBB model and the pharmacokinetic data in the in vivo human brain is mandatory to demonstrate the predictive value of the in vitro screening tools