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Preventive use of SERMs like tamoxifen can block estrogen receptors in breast tissue without affecting estrogen elsewhere in the body

Two additional substitutions further enhance the in vivo activity of efruxifermin: A180E, which increases affinity for KLB, and L98R, which decreases aggregation (238)

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Studies have also shown that -HB increases oxidative phosphorylation via a Complex II-dependent mechanism