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Abbreviations MSM: methyl sulphonyl methane Vit C: vitamin C GPx: glutathione peroxidise GST: glutathione transferase GR: glutathione reductase HO: heme oxygenase ROS: reactive oxygen species RNS: reactive nitrogen species NO: nitric oxide CO: carbon monoxide GSH: glutathione

The animals were group-housed until one week before treatment initiation, after which they were given daily subcutaneous injections of vehicle or Cagrilintide at doses of 0.3, 3, or 30 nmol/kg for 21 days