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Biocatalytic methylation using engineered methyltransferases enables efficient modification of fisetin, leading to improved solubility, chemical stability, and lipophilicity, thereby enhancing its development and application (330)

Nevertheless, despite demonstrating potent in vivo effects, neither study performed side-by-side dose-response benchmarking against clinical ACE inhibitors (e.g., lisinopril or captopril) under identical assay conditions

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In conclusion, our findings demonstrated that dexamethasone treatment effectively reduced tendinopathy in both human retrospective analyses and experimental models