cjc-1295 ipamorelin peptide side effects Effects: Common Risks, Safety & When to Stop What are the side effects

cyPG 15-deoxy-DELTA12,14-PGJ2 and biotinylated 15d-PGJ2, mass spectrometry analysis, overview, irreversible inhibition - quercetin - inhibition of isozymes GST M1-1 and M2-2 resveratrol - inhibition of isozymes GST A2-2, M1-1, M2-2, and P1-1 S-(2,4-dinitrophenyl)glutathione - product inhibition S-(2,4-dinitrophenyl)GSH - - S-(4-azidophenacryl)-glutathione - competitive inhibitor, 27% loss of activity after 5 min S-hexyl glutathione - S-hexylglutathione S-methyl-GSH - - S-Methylglutathione - competitive spiromesifen - a potent reversible inhibitor toward hGSTA1-1, mixed-type inhibition, spiromesifen binds specifically to the enzyme presumably at a position that partially overlaps with both the G- and H-site, a site distinct from binding of dieldrin, binding structure overview tert-butyl N-acryloyl-N-(4-phenylthiazol-2-yl)glycinate - Tic-Cys(Acm)-Gly 68.5% remaining activity at 0.0003 mM Tic-Cys-Aib 80.1% remaining activity at 0.0003 mM Tic-Cys-Sar 53% remaining activity at 0.0003 mM Tributyltin acetate - - EDTA - 0.023 - 0.417 (+)-2-bromo-3-(4-nitrophenyl)propanoic acid 4.2 - 8.8 (R)-styrene-7,8-oxide 0.8 - 2.4 (R,R)-1-phenylpropylene oxide 0.035 - 0.1 (R,R)-trans-stilbene oxide 1.3 - 4.9 (S)-styrene-7,8-oxide 2.2 - 3.8 (S,S)-1-phenylpropylene oxide 0.08 - 0.12 (S,S)-trans-stilbene oxide 0.27 - 0.84 1,2-dichloro-4-nitrobenzene 0.13 - 1.84 1,2-epoxy-3-(p-nitrophenoxy)propane 0.6 - 1 1,3-Bis-(2-chloroethyl)-1-nitrosourea 0.17 - 6.6 1-chloro-2,4-dinitrobenzene 0.232 3,4-dinitrobenzanilide in phosphate buffered saline, pH 7.4, at 37C 0.002 - 0.011 7-chloro-4-nitrobenz-2-oxa-1,3-diazole 2.24 acetyl-gamma-Glu-Cys-Gly mutant enzyme I104V/A113V, at pH 7.4 and 25C 0.005 brostallicin - pH 6.5, 25C, GSTM2-2 0.00324 cryptophycin 52 - pH 7.4, 37C 0.3 - 8 cumene hydroperoxide 0.06 - 0.21 Ethacrynic acid 1.48 gamma-Glu-Cys-Aib mutant enzyme I104V/A113V, at pH 7.4 and 25C 0.014 - 3.18 gamma-Glu-Cys-Sar 0.003 - 123.6 glutathione 0.0139 - 1.76 GSH 3.22 Hyp-Cys-Gly wild type enzyme, at pH 7.4 and 25C 0.083 iodobutane pH 8.0, 30C, recombinant wild-type enzyme 0.058 iodohexane pH 8.0, 30C, recombinant wild-type enzyme 0.085 iodomethane pH 8.0, 30C, recombinant wild-type enzyme 0.064 - 0.768 maleylacetone 1.25 Tic-Cys-Gly wild type enzyme, at pH 7.4 and 25C additional information additional information - 0.19 - 13 (+)-2-bromo-3-(4-nitrophenyl)propanoic acid 2.7 - 4.8 (R)-styrene-7,8-oxide 0.83 - 17.7 (R,R)-1-phenylpropylene oxide 0.37 - 7.7 (R,R)-trans-stilbene oxide 2.3 - 8.4 (S)-styrene-7,8-oxide 1.1 - 9 (S,S)-1-phenylpropylene oxide 0.07 - 0.46 (S,S)-trans-stilbene oxide 110 - 320 1,2-dichloro-4-nitrobenzene 31 - 302 1,2-epoxy-3-(p-nitrophenoxy)propane 0.035 - 3.6 1,3-Bis-(2-chloroethyl)-1-nitrosourea 1.19 - 761 1-chloro-2,4-dinitrobenzene 106 1-Fluoro-2,4-dinitrobenzene - - 367 3,4-dinitrobenzanilide in phosphate buffered saline, pH 7.4, at 37C 1.03 acetyl-gamma-Glu-Cys-Gly mutant enzyme I104V/A113V, at pH 7.4 and 25C 200 - 9600 cumene hydroperoxide 1.91 gamma-Glu-Cys-Aib wild type enzyme, at pH 7.4 and 25C 0.39 - 0.56 gamma-Glu-Cys-Sar 0.17 - 47.3 glutathione 0.19 - 1700 GSH 1.04 Hyp-Cys-Gly wild type enzyme, at pH 7.4 and 25C 0.037 iodobutane pH 8.0, 30C, recombinant wild-type enzyme 0.068 iodohexane pH 8.0, 30C, recombinant wild-type enzyme 9.16 iodomethane pH 8.0, 30C, recombinant wild-type enzyme 0.347 - 464 maleylacetone 0.31 Tic-Cys-Gly wild type enzyme, at pH 7.4 and 25C 0.036 - 6.3 1,3-Bis-(2-chloroethyl)-1-nitrosourea 0.737 - 17.3 1-chloro-2,4-dinitrobenzene 0.46 acetyl-gamma-Glu-Cys-Gly mutant enzyme I104V/A113V, at pH 7.4 and 25C 4 - 11 brostallicin 1.29 gamma-Glu-Cys-Aib wild type enzyme, at pH 7.4 and 25C 0.12 - 39.68 gamma-Glu-Cys-Sar 0.00304 - 34 glutathione 0.32 Hyp-Cys-Gly wild type enzyme, at pH 7.4 and 25C 0.701 iodobutane pH 8.0, 30C, recombinant wild-type enzyme 1.17 iodohexane pH 8.0, 30C, recombinant wild-type enzyme 107 iodomethane pH 8.0, 30C, recombinant wild-type enzyme 0.25 Tic-Cys-Gly wild type enzyme, at pH 7.4 and 25C 0.037 1-chloro-2,4-dinitrobenzene - pH 6.5, 25C, GSTM2-2 0.071 2-([(1-methyl-1H-pyrrol-2-yl)sulfonyl]methyl)-N-[(1E)-(4-nitrophenyl)methylene]aniline - pH 6.5, 25C 0.00061 2-chloro-N-(3-(morpholinosulfonyl)-4-(trifluoromethyl)phenyl)-acetamide - at pH 8.0 and 37C 0.0012 2-chloro-N-(3-(N,N-dimethylsulfamoyl)-4-(trifluoromethyl)-phenyl)acetamide - at pH 8.0 and 37C 0.00044 2-chloro-N-[4-chloro-3-(N,N-dimethylsulfamoyl)phenyl]acetamide - at pH 8.0 and 37C 0.00021 - 0.0088 5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione 0.068 bromosulfophthalein - minor form 0.0001 - 0.0023 dieldrin 0.028 glutathione - pH 6.5, 25C, GSTM2-2 0.002 - 0.032 Hematin 0.1 S-Methylglutathione - - 0.0004 - 0.0021 spiromesifen additional information additional information - 0.0008 (4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)methanesulfonyl fluoride Homo sapiens - at pH 8.0 and 37C 0.01 (E)-2-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)ethene-1-sulfonyl fluoride Homo sapiens - IC50 above 0.01 mM, at pH 8.0 and 37C 0.1 (E)-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)but-2-enamide Homo sapiens - IC50 above 0.1 mM, at pH 8.0 and 37C 0.01 1-(4-benzylpiperidin-1-yl)prop-2-en-1-one Homo sapiens IC50 above 0.01 mM, at pH 8.0 and 37C 0.01 1-(4-phenylpiperidin-1-yl)prop-2-en-1-one Homo sapiens IC50 above 0.01 mM, at pH 8.0 and 37C 0.01 2-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)ethane-1-sulfonyl fluoride Homo sapiens - IC50 above 0.01 mM, at pH 8.0 and 37C 0.00001 - 0.011 2-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)imidazole 0.1 2-chloro-5-((cyanomethyl)amino)-N,N-dimethylbenzenesulfonamide Homo sapiens - IC50 above 0.1 mM, at pH 8.0 and 37C 0.1 2-chloro-N,N-dimethyl-5 -(oxiran-2-ylmethyl) -benzenesulfonamide Homo sapiens - IC50 above 0.1 mM, at pH 8.0 and 37C 0.0012 2-chloro-N,N-dimethyl-5-(oxiran-2-yl)benzenesulfonamide Homo sapiens - at pH 8.0 and 37C 0.00129 2-chloro-N,N-dimethyl-5-(vinylsulfonamido)-benzenesulfonamide Homo sapiens at pH 8.0 and 37C 0.00071 2-chloro-N-(2-(N,N-dimethylsulfamoyl)-[1,1'-biphenyl]-4-yl)-acetamide Homo sapiens - at pH 8.0 and 37C 0.00025 2-chloro-N-(3-(morpholinosulfonyl)-4-(trifluoromethyl)phenyl)-acetamide Homo sapiens - at pH 8.0 and 37C 0.00021 2-chloro-N-(3-(N,N-dimethylsulfamoyl)-4-(trifluoromethoxy)-phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.00006 2-chloro-N-(3-(N,N-dimethylsulfamoyl)-4-(trifluoromethyl)-phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.00013 2-chloro-N-(3-(N,N-dimethylsulfamoyl)-4-iodophenyl)-acetamide Homo sapiens - at pH 8.0 and 37C 0.0000056 2-chloro-N-(4-(2-hydroxyphenyl)thiazol-2-yl)-N-((3-methylisoxazol-5-yl)methyl)acetamide Homo sapiens at pH 8.0 and 37C 0.00016 2-chloro-N-(4-chloro-3-(morpholinosulfonyl)phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.01 2-chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-propanamide Homo sapiens - IC50 above 0.01 mM, at pH 8.0 and 37C 0.0002 2-chloro-N-(4-chloro-3-(N-((tetrahydrofuran-2-yl)methyl)-sulfamoyl)phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.00018 2-chloro-N-(4-chloro-3-(N-(2-hydroxyethyl)-N-methylsulfamoyl)phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.0007 2-chloro-N-(4-chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-acetamide Homo sapiens - at pH 8.0 and 37C 0.00008 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)-N-methylsulfamoyl)phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.00003 2-chloro-N-(4-chloro-3-(N-(2-methoxyethyl)sulfamoyl)phenyl)-acetamide Homo sapiens - at pH 8.0 and 37C 0.00016 2-chloro-N-(4-chloro-3-(N-(3-methoxypropyl)-N-methylsulfamoyl)phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.00011 2-chloro-N-(4-chloro-3-(N-(3-methoxypropyl)sulfamoyl)phenyl)-acetamide Homo sapiens - at pH 8.0 and 37C 0.00034 2-chloro-N-(4-chloro-3-(N-(tetrahydrofuran-3-yl)sulfamoyl)-phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.00007 2-chloro-N-(4-chloro-3-(N-isopropylsulfamoyl)phenyl)-acetamide Homo sapiens - at pH 8.0 and 37C 0.00058 2-chloro-N-(4-chloro-3-(N-methylsulfamoyl)phenyl)acetamide Homo sapiens - at pH 8.0 and 37C 0.000021 - 0.00013 2-chloro-N-[4-chloro-3-(N,N-dimethylsulfamoyl)phenyl]acetamide 0.0032 3-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)propane-1-sulfonyl fluoride Homo sapiens - at pH 8.0 and 37C 0.0003 - 0.066 3-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)propionic acid 0.01 3-chloro-N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-propenamide Homo sapiens - IC50 above 0.01 mM, at pH 8.0 and 37C 0.00003 - 0.056 4-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)butanol 0.06 4-(acryloylamino)-N-(5-[[5-([5-[(2-carbamimidamidoethyl)carbamoyl]-1-methyl-1H-pyrrol-3-yl]carbamoyl)-1-methyl-1H-pyrrol-3-yl]carbamoyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-2-carboxamide Homo sapiens - pH 6.5, 25C, with isozyme GSTM2-2 0.0068 5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione Homo sapiens - pH and temperature not specified in the publication 0.0054 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-chlorobenzyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0039 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0038 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-methoxyphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0033 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-nitrobenzyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.04 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.004 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0036 5-[2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.002 5-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-chlorobenzyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0024 5-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0034 5-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-hydroxyphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0023 5-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-nitrobenzyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0039 5-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.004 5-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0018 5-[2,3-dimethyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0014 5-[3-bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0013 5-[3-bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0032 5-[3-bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.002 5-[3-bromo-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0007 5-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0007 5-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0021 5-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0006 5-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0035 5-[3-methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-fluorophenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0021 5-[3-methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-hydroxyphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0029 5-[3-methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-nitrobenzyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0033 5-[3-methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-(4-trifluoromethylphenyl)-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.005 5-[3-methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-methyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.002 5-[3-methyl-4-(2-methylene-1-oxopropyl)phenoxymethyl]-3-phenyl-1,2,4-oxadiazol Homo sapiens - 25C, isozyme GSTP1-1 0.0018 - 0.1 6-(7-nitro-2,1,3-benzoxadiazol-4-ylamino)hexanol 0.00001 - 0.025 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol 0.00004 - 0.005 curcumin Homo sapiens - pH 7.4, 30C, purified recombinant isozymes GST A1-1, A2-2, M1-1, M2-2, and P1-1 0.0179 - 0.0983 dieldrin 0.00013 - 0.005 ellagic acid Homo sapiens - pH 7.4, 30C, purified recombinant isozymes GST A1-1, A2-2, M1-1, M2-2, and P1-1 0.0034 Ethacrynic acid Homo sapiens - - 0.00027 ethyl 2-acrylamido-4-phenylthiazole-5-carboxylate Homo sapiens at pH 8.0 and 37C 0.00101 ethyl 2-acrylamido-4-phenylthiophene-3-carboxylate Homo sapiens at pH 8.0 and 37C 0.00022 ethyl 2-acrylamido-5-phenylthiophene-3-carboxylate Homo sapiens at pH 8.0 and 37C 0.00057 ethyl N-acryloyl-N-(4-phenylthiazol-2-yl)glycinate Homo sapiens at pH 8.0 and 37C 0.004 - 0.005 genistein Homo sapiens - pH 7.4, 30C, purified recombinant isozymes GST M1-1 and M2-2 0.001 - 0.002 kaempferol Homo sapiens - pH 7.4, 30C, purified recombinant isozymes GST M1-1 and M2-2 0.01 methyl (E)-4-((4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-amino)but-2-enoate Homo sapiens IC50 above 0.01 mM, at pH 8.0 and 37C 0.00037 methyl N-acryloyl-N-(4-phenylthiazol-2-yl)glycinate Homo sapiens at pH 8.0 and 37C 0.00000032 N-((3-methylisoxazol-5-yl )methyl)-N-(4-(4-chloro-2-hydroxylphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00000022 N-((3-methylisoxazol-5-yl)methyl)-N-(4-(2-hydroxylphenyl)-thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00036 N-((3-methylisoxazol-5-yl)methyl)-N-(4-(2-methoxyphenyl)-thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00004 N-((3-methylisoxazol-5-yl)methyl)-N-(4-(4-fluoro-2-hydroxylphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.000025 N-((3-methylisoxazol-5-yl)methyl)-N-(4-(4-trifluoromethylphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.000051 N-((3-methylisoxazol-5-yl)methyl)-N-(4-phenylthiazol-2-yl)-acrylamide Homo sapiens at pH 8.0 and 37C 0.01 N-(1-benzyl-1H-pyrazol-4-yl)acrylamide Homo sapiens IC50 above 0.01 mM, at pH 8.0 and 37C 0.01 N-(1-phenyl-1H-pyrazol-4-yl)acrylamide Homo sapiens IC50 above 0.01 mM, at pH 8.0 and 37C 0.00023 N-(2-((2-morpholinoethyl)amino)-2-oxoethyl)-N-(4-phenylthiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00008 N-(2-(cyclohexylamino)-2-oxoethyl)-N-(4-phenylthiazol-2-yl)-acrylamide Homo sapiens at pH 8.0 and 37C 0.00003 N-(2-(oxetan-3-ylamino)-2-oxoethyl)-N-(4-phenylthiazol-2-yl)-acrylamide Homo sapiens at pH 8.0 and 37C 0.00053 N-(2-morpholino-2-oxoethyl)-N-(4-phenylthiazol-2-yl)-acrylamide Homo sapiens at pH 8.0 and 37C 0.00088 N-(4-(2-chlorophenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00158 N-(4-(2-fluorophenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00086 N-(4-(2-hydroxylphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00019 N-(4-(2-hydroxyphenyl)thiophen-2-yl)-N-((3-methylisoxazol-5-yl)methyl)acrylamide Homo sapiens at pH 8.0 and 37C 0.01 N-(4-(2-methoxyphenyl)thiazol-2-yl)acrylamide Homo sapiens IC50 above 0.01 mM, at pH 8.0 and 37C 0.00122 N-(4-(3,4-dioxylphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.0006 N-(4-(3-chlorophenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00017 N-(4-(4-chlorophenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.01 N-(4-(4-hydroxylphenyl)thiazol-2-yl)acrylamide Homo sapiens IC50 above 0.01 mM, at pH 8.0 and 37C 0.00449 N-(4-(4-methoxyphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00081 N-(4-(4-methylphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.0003 N-(4-(4-trifluoromethylphenyl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.0004 N-(4-(naphthalen-2-yl)thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00015 N-(4-bromo-3-(N,N-dimethylsulfamoyl)phenyl)-2-chloroacetamide Homo sapiens - at pH 8.0 and 37C 0.1 N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-2-cyanoacetamide Homo sapiens - IC50 above 0.1 mM, at pH 8.0 and 37C 0.1 N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-2-fluoroacetamide Homo sapiens - IC50 above 0.1 mM, at pH 8.0 and 37C 0.01 N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)-2-oxopropanamide Homo sapiens - IC50 above 0.01 mM, at pH 8.0 and 37C 0.00314 - 1 N-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)acrylamide 0.00311 N-(4-phenyl-5-methyl-thiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00074 N-(4-phenylthiazol-2-yl)-N-(pyridin-3-ylmethyl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00047 N-(4-phenylthiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00103 N-(5-phenylthiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 0.00204 N-acryloyl-N-(4-phenylthiazol-2-yl)glycine Homo sapiens at pH 8.0 and 37C 0.00072 N-benzyl-N-(4-phenylthiazol-2-yl)acrylamide Homo sapiens at pH 8.0 and 37C 1 N1-(4-chloro-3-(N,N-dimethylsulfamoyl)phenyl)oxalamide Homo sapiens - IC50 above 1.0 mM, at pH 8.0 and 37C 0.0003 - 0.0005 quercetin Homo sapiens - pH 7.4, 30C, purified recombinant isozymes GST M1-1 and M2-2 0.0121 - 0.0795 spiromesifen 0.00015 tert-butyl N-acryloyl-N-(4-phenylthiazol-2-yl)glycinate Homo sapiens at pH 8.0 and 37C additional information additional information Homo sapiens - - - 0.0029 - 0.0036 - with 1-chloro-2,4-dinitrobenzene as substrate 0.019 mutant enzyme D90N, in phosphate buffer (pH 6.5), at 25C 0.03 - with cumene hydroperoxide as substrate 0.039 using 3-iodopropylbenzene as substrate 0.066 using 3-iodopropylbenzene as substrate 0.07 - with styrene oxide as substrate 0.081 using 1,6-diiodohexane as substrate 0.086 using iodohexane as substrate 0.1 using 3-iodopropylbenzene as substrate 0.18 mutant enzyme R74Q, in phosphate buffer (pH 6.5), at 25C 0.335 purified recombinant enzyme, substrate 2-hydroxyethyl disulfide 0.37 - with 1,2-epoxy-3-(4-nitrophenoxy)propane as substrate 0.5 mutant enzyme Y7F, at 30C, in 0.1 M potassium phosphate buffer, pH 6.5 0.53 isozyme GST A2-2, using azathioprine as a substrate 0.56 using 1,4-diiodobutane as substrate 0.7 - with adenine propenal, isoenzyme A1-1 0.81 using 1,4-diiodobutane as substrate 0.84 - 0.92 - with glutathione as substrate 0.86 - with acrolein, isoenzyme A1-1 0.91 using 1,4-diiodobutane as substrate 1.03 using 1,6-diiodohexane as substrate 1.38 using iodohexane as substrate 1.4 mutant enzyme A113V, with ethacrynic acid 1.5 - 8.3 - with cumene hydroperoxide as substrate 1.7 wild type enzyme, with ethacrynic acid 1.8 mutant enzyme I104V, with ethacrynic acid 10.45 purified recombinant enzyme, substrate 1-chloro-2,4-dinitrobenzene in absence of 10 mM EDTA 102 mutant enzyme T67A, in phosphate buffer (pH 6.5), at 25C 105 - with 1-chloro-2,4-dinitrobenzene as substrate 129 - purified recombinant isozyme GST P1-1 14.56 purified recombinant enzyme, substrate 1-chloro-2,4-dinitrobenzene in presence of 10 mM EDTA 157 - purified recombinant isozyme GST M1-1 182 - purified recombinant isozyme GST M2-2 2.52 mutant enzyme C14A/C47A/C101A/C169A, at 30C, in 0.1 M potassium phosphate buffer, pH 6.5 26.3 - with acrolein, isoenzyme P1-1 3 mutant enzyme I104V/A113V, with 7-chloro-4-nitrobenz-2-oxa-1,3-diazole 3 - 3.9 using 1,2-diiodoethane as substrate 3.4 mutant enzyme R70Q, in phosphate buffer (pH 6.5), at 25C 31.5 using 1,2-diiodoethane as substrate 33 - 94 - with 1-chloro-2,4-dinitrobenzene as substrate 36.13 mutant enzyme C47A/C101A, at 30C, in 0.1 M potassium phosphate buffer, pH 6.5 4 mutant enzyme A113V, with 7-chloro-4-nitrobenz-2-oxa-1,3-diazole 4.75 mutant enzyme C14A/C47A/C101A, at 30C, in 0.1 M potassium phosphate buffer, pH 6.5 4.96 - purified wild-type GST T1-1, substrate 1-iodomethane 53.2 isozyme GST A2-2, using 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole as a substrate 56.4 using 1,2-diiodoethane as substrate 60 mutant enzyme I104V, with 1-chloro-2,4-dinitrobenzene 61.07 His-tagged wild type enzyme, at 30C, in 0.1 M potassium phosphate buffer, pH 6.5 61.8 isozyme GST A1-1, using 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole as a substrate 66 - species with very low isoelectric point from erythrocytes 7.05 - with acrolein, isoenzyme M1-1 7.26 isozyme GST A3-3, using 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole as a substrate 7.84 - purified wild-type GST T1-1, substrate 1,2-epoxy-3-(4-nitro-phenoxy)propane 70 mutant enzyme I104V/A113V, with 1-chloro-2,4-dinitrobenzene 71.7 untagged wild type enzyme, at 30C, in 0.1 M potassium phosphate buffer, pH 6.5 75 wild type enzyme, in phosphate buffer (pH 6.5) 77 - with adenine propenal, isoenzyme P1-1 78 - purified recombinant isozyme GST A2-2 80 - 272 - with 1-chloro-2,4-dinitrobenzene as substrate 84 - purified recombinant isozyme GST A1-1 10 - activity with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid 6.5 - 8 assay at, dependent on the substrate 6.5 - 11 - pH 6.5: about 65% of maximal activity, pH 11: about 85% of maximal activity, activity with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid - brenda O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 - brenda - brenda - - brenda - - brenda - a small cell lung carcinoma cell line brenda - brenda - brenda - brenda - brenda - brenda - - brenda - a myeloid leukemia cell line brenda - GSTP1-1 is overexpressed in liver cancer cells brenda - - brenda - - brenda O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 GSTM2-2 is largely muscle specific brenda - brenda - brenda - - brenda - - brenda - - brenda - brenda - - brenda - - brenda O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 - brenda - integral membrane protein brenda - - - brenda - - brenda - brenda - matrix brenda Highest Expressing Human Cell Lines Cell Line Links Gene Links evolution O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions physiological function O43708, Q9H4Y5, Q16772, P09211, P09210, P08263, P09488, O15217, P28161, Q03013, P46439, P78417, O60760, Q7RTV2, P21266, P0CG30 all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions

qPCR and Immunofluorescence analysis demonstrated dose-dependent telomere length extension in normal cells through hTERT and telomerase upregulation

Many clients use both, and IV for the cellular foundation, topical for surface protection

Moreover, glutathione has been shown to enhance skin elasticity