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Nrf2 activation mitigates this process by attenuating intracellular ROS accumulation, thereby indirectly suppressing inflammatory signals such as NF-B 43

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In a Phase II readout released in August 2022, the pharma touted a 15.6% drop in body weight in patients taking CagriSema, versus 5.1% in comparators on semaglutide alone and 8.1% in patients treated with only cagrilintide