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499 Measurements of NA-induced changes in cyclic adenosine monophosphate (cAMP) revealed an increased sensitivity of this second messenger to changes in extracellular lactate, indicating altered signalling landscape at the plasma membrane in relation to lactate homoeostasis

For example, studies have found that early-onset ARDS is associated with severe hemorrhagic shock, while late-onset ARDS is often characterized by pneumonia and multiple organ damage (36)

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