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A 2015 study published in the Canadian Journal of Respiratory Therapy stated, Vaporization of cannabis is likely less harmful than smoking and Vaporizers show promise for cannabis users who want to avoid pulmonary problems and prefer a more rapid onset than edibles provide. However, the study also cautioned, Researchers have yet to gather some of the most necessary data regarding the topic. There have been no published randomized clinical trials investigating vaporization with long-term follow-up, the study concluded

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Interestingly, vascular oxidative stress and endothelial dysfunction correlated with the PN count of the UFPs rather than the inhaled particle mass or NO 2 concentration