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These pipes were for personal use: when an individual wished to communicate with his totem, or the spirit world, he would smoke his tobacco pipe, which had been shaped to represent his totemic animal or a recognized messenger with the spirits

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Scientists found that when they measured electrical properties of the brain tissue of rats exposed to nicotine, BOTH pacemaker neurons were affected the GABA producing cells and glutamate producing cellswhere in the latter the brief nicotine application induced a condition known as LONG-TERM POTENTIATION