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The timeline for expected therapeutic response may vary based on the condition being treated and individual patient factors

MSKCC and Columbia University jointly hold patents on hydroxamic acid-based polar compounds, including vorinostat (SAHA), that were exclusively licensed to Aton Pharma Inc., a biotechnology company that was acquired by Merck Inc

2.5 Quality assessment and risk of bias In line with PRISMA guidelines, the assessment of methodological quality was conducted to evaluate the strength of evidence, recognising that methodological limitations may introduce bias

Studies have shown that systemic OGP administration increases bone formation rate and trabecular bone volume in intact animals and accelerates fracture healing in models of skeletal injury