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Steric hindrance from the increased side-chain volume of E14 Cagri and R17 Cagri promotes a shift of the -helix of Cagri away from ECL2 and a slight expansion of the peptide binding pocket at the extracellular side of the CTR TM domain, relative to those observed with rAmy/San385-bound AMYR complexes

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Recently, the demand for aluminum in the world has contributed to increased alkalinity in surrounding ecosystems because mining and disposing of the alkaline bauxite residue (Kong et al., 2017)