Giralt S, Estey E, Albitar M, van Besien K, Rondn G, Anderlini P, O'Brien S, Khouri I, Gajewski J, Mehra R, Claxton D, Andersson B, Beran M, Przepiorka D, Koller C, Kornblau S, Krbling M, Keating M, Kantarjian H, Champlin R
The activated HIFs is able to induce the expression of various gene products, such as glycolysis- and EMT program-associated molecules (CXCR4, SNAIL and TWIST), the induced pluripotency-associated transcription factors (OCT-3/4, NANOG, and SOX2), angiogenic factors (VEGF) and microRNAs, which are vital to self-renewal, survival, invasion, metastasis, angiogenesis, metabolic reprogram, and treatment resistance of cancer cells
And very, very early on, you know, you have an aha moment in your life
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