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2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines

Evidence: Phase 2 trials (e.g., REINFORCE program) showed up to 15-20% body weight reduction over 32-68 weeks when co-administered with semaglutide, outperforming semaglutide monotherapy (10-15% loss)

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Long-Term Safety Evidence While many peptide therapies have been evaluated only in short-term trials, AOD-9604 benefits from long-term safety data extending to 24 weeks of continuous administration