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MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice

Furthermore, understanding how copper homeostasis is dysregulated in comorbid conditions (e.g., diabetes and HF) will provide a more comprehensive pathophysiological perspective

5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame

Gai HF, An JX, Qian XY, Wei YJ, Williams JP, Gao GL