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used in long-term human clinical trials Intravenous injection Used primarily for pharmacokinetic characterization and acute dosing studies in humans Intraperitoneal injection Standard route for chronic rodent studies

If any signs of injection site infection develop (increasing redness, warmth, swelling, or pain), discontinue use and consult a healthcare provider

58 59 Nitrous oxide toxicity The Association of British Neurologists has recently issued guidance on recognising and managing nitrous oxide toxicity associated with B 12 deficiency

We recognize the unique needs of vegetarians and vegans, who might not get enough B12 from plant-based diets