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In 1961, Leonard Hayflick demonstrated that human fetal cells have 50 to 60 generations of limited replication potential, which was subsequently termed the Hayflick limit or replicative senescence

Silybin treatment tended to decrease the levels of TNF-, IL-1, and IL-6, which induced a significant increase in the levels of the tight junction proteins occludin and ZO-1, which could be effective in treating intestinal barrier inflammation and alleviating the effects of MASLD [136]

Sci New York NY (2012) 336(6080):48993

To view a copy of this licence, visit About this article Cite this article Bourebaba, N., Domagaa, J