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Extensive structure modification on luteolin-cinnamic acid conjugates leading to BACE1 inhibitors with optimal pharmacological properties

After evaporation of the solvents, flash chromatography was performed and the following preparative reversed-phase HPLC separation allowed to obtain APAP-CYS in yield of 21% after two reaction steps

Theyre legal to use only in experimental settings but are increasingly available online or from wellness clinics and other unregulated entities