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doi: 10.3389/fphys.2017.00551 216 VeitchSNjockM-SChandyMSirajMAChiLMakHet al

15 DVL proteins located in the cytoplasm are pivotal in the transduction of WNT signalling from the receptor level to the intracellular compartment and contain three highly conserved domains: the DIX domain at the N-terminal side (the site interacts with AXIN), the PZD domain in the central part, and the DEP domain at the C-terminal side