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Oxidative damage to proteins involved in the acrosome reaction, such as acrosin and hyaluronidase, impairs the sperms ability to release these enzymes, preventing successful penetration of the oocyte (79, 80)

[PMC free article: PMC4415205] [PubMed: 25695910] 63

Interestingly, a small trial in 30 premenopausal women found that daily multivitamin supplementation for ten weeks did not improve overall mood, but when the supplement also contained 7 mg/day of zinc (RDA=8 mg/day), the authors noted significant improvements in two components of POMS: the anger-hostility and the depression-dejection scores (140)

Curcuminoid-containing supplements taken on an empty stomach may cause gastritis and peptic ulcer disease (108)