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All eight B vitamins work together to support energy production, so no single B vitamin is universally best. However, vitamin B12 is commonly associated with energy because its essential for red blood cell formation and nervous system function, while thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5) and vitamin B6 also help convert food into usable energy

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Under physiological conditions, it supports synaptic plasticity [346], whereas under pathological states, such as during astrocytic necroptosis, proBDNF may exert neurotoxic effects and promote apoptotic signaling [349]