Abbreviations DKD: Diabetic kidney disease UAE: Albumin excretion rate UACR: Urine albumin/creatinine ratio hbA1c%: Glycosylated hemoglobin MDA: Malonaldehyde CKD: Chronic kidney disease ESRD: End-stage renal disease GFR: Glomerular filtration rate NOX1: NADPH oxidase 1 IL-6: Interleukin 6 MCP-1: Monocyte chemoattractant protein-1 TGF-: Transforming growth factor- NADPH: Nicotinamide adenine dinucleotide phosphate VEGF: Vascular endothelial growth factor GBM: Glomerular basement membrane NF-B: Nuclear factor B TNF-: Tumor necrosis factor-alpha CAMs: Cell adhesion molecules MAPK: Mitogen-activated protein kinase AP-1: Transcription factor activator protein 1 JNK: C-Jun N-terminal kinase OS: Overall survival NO: Nitric oxide AGEs: Advanced glycation end products PKC: Protein kinase C ECM: Extracellular matrix CTGF: Connective tissue growth factor TGF-1: Transforming growth factor-1 Nrf2: Nuclear factor (erythroid-derived 2)-like 2 HO-1: Hemoglobin oxygenase-1 (hypocretin-1) NQO1: Quinone oxidoreductase (NAD(P)H Quinone Dehydrogenase 1) CAT: Catalase SOD: Superoxide dismutase GPx: Glutathione peroxidase NR1: Notoginsenoside R1 HFD: High-fat diet STZ: Streptozotocin HSYA: Hydroxyl safflower yellow A GSH-Px: Glutathione RAGE: Receptor for advanced glycosylation end products NFE2L2: Nuclear factor erythroid 2-related factor 2 HMOX1: Heme oxygenase-1 SLC30A7: The 7th member of SLC30 family SGLT2: Sodium/glucose co-transporter type 2 Sp1: Specificity protein 1 TLR4: Toll-like receptor 4 PGC-1: Proliferator-activated receptor coactivator-1 GCN5L1: General control of amino acid synthesis 5-like 1 MnSOD: Manganese superoxide dismutase LGR6: Leucine-rich repeat domain-containing G protein-couple receptor 6 cAMP: Cyclic adenosine 3,5 -monophosphate SOD2: Mn-SOD CuNPs: Hydrogen sulfide GST: Glutathione S transferase RCTs: Randomized controlled trials SCr: Serum creatinine MD: Mean difference SMD: Standard mean difference ACEI: Angiotensin-converting enzyme inhibitor ARB: Angiotensin II receptor antagonist ROS: Reactive oxygen species References de Boer IH
However, most ferroptosis-related drugs for breast cancer are still in the preclinical stage ( Formononetin, an isoflavone compound derived from a variety of medicinal plants and herbs such as including Trifolium pratense and Astragalus membranaceus , has been identified as exhibiting anticancer potential against various cancer types, such as cervical, head and neck, colon, breast and ovarian cancers ( via the inhibition of Akt activity (Zhou et al., 2019), indicating its potential as a therapeutic agent for breast cancer inhibition
By shedding light on this powerful compound, we aim to provide insights into maintaining the luster and color of your hair, keeping it as vibrant and healthy as possible
High levels of fat and cholesterol disrupt lipid metabolism balance, leading to mitochondrial dysfunction (110)
