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The neurogenesis findings expand the AEDG sequences research relevance beyond telomere biology and pineal signaling into developmental biology and epigenetics domains where the enhanced stability and membrane permeability of the modified form may offer practical advantages for longer-duration experimental protocols

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Among the salient indications, inhaled NO is used for acute pulmonary vasoreactivity testing and severe hypoxia in pulmonary arterial hypertension (PAH), nitrates are used extensively in ischemic heart disease and heart failure, sGC stimulators and activators are used for PAH, and PDE5 inhibitors are used for erectile dysfunction, PAH and benign prostatic hyperplasia