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There are specific, documented cases where a qualified dermatologist might consider it: severe and resistant pigmentation conditions, including certain presentations of melasma that have not responded adequately to topical treatments, oral supplements, and professional procedures over an extended period

[DOI] [PubMed] [Google Scholar] 14.Clinical pharmacology of the dietary supplement creatine monohydrate

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A vitamin B-12 supplement of 500 g/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status