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Excessive alcohol use : includes binge drinking, heavy drinking, any alcohol use by people under the age of 21 minimum legal drinking age, and any alcohol use by pregnant women (CDC, Alcohol and public health , n

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Among them, motif 1/3 were found in all NtIDDs, motif 2/4/5/6/7 were distributed in most of NtIDDs, motif 8 was specifically found in NtIDD1/9/6/21 , motif 9 was found in NtIDD5/15/7/24/1/23/4 , and motif 10 was found in NtIDD5/15/7/24/1/23/6/21/22