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Fun fact: It was first discovered in 1907 and naturally occurs in the production of sake, soy sauce, and miso

It is unclear to what extent the reduction in lean mass is attributable to loss of skeletal muscle mass per se, which comprises only one component of total body lean mass in mice, but the lack of effect on fat mass is consistent with the reported paucity of IGF-1Rs on mature adipocytes

Clinical evidence shows: For individuals with mild to moderate dyslipidemia, berberine could be a natural complementary option under medical guidance

Hexokinase 2 (HK2), which catalyzes the first step of glycolysis, is stabilized by the deubiquitinase CSN5 in HCC, promoting metastasis