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: BPC 157 - 10

If applied locally via injection, as was done in the study, there is also a risk of structural damage as the needle could break the fragile external walls that protect the discs

Bioinformatics 27 (21), 29572963

They concluded that the risk-edited cells increased a T cell activation profile following non-specific TCR engagement, which mimicked the observations exhibited by PTPN22 knockout cells, suggesting the risk variant acts as a loss-of-function mutant that reduces the ability of LYP to inhibit TCR activation (74)