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In addition to important role in the folate cycle that is involved in the reduction of BH 2 to BH 4 , it is an important component in homocysteine metabolism via the methionine cycle (Figure 8), and is critical for neural tube development

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doi: 10.3233/JAD-170512

Accompanied by the release of cytochrome c into the cytoplasm, apoptotic protease activator-1 (Apaf-1) can respond to the release of cytochrome c and bind to it to form multimers, as well as contributing to the binding of caspase-9 to form apoptotic vesicles and induce apoptosis