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Acta Pharmacol Sin 30 , 113119 (2009)

P.g administration also induces significant fungal dysbiosis (mycobiome), enriching pathogenic species such as Pyricularia pennisetigena , Alternaria alternata , and Candida glabrata , which correlate with alterations in host metabolic pathways, especially tryptophan metabolism ( P.g and its metabolites directly and indirectly compromise gut integrity by downregulating the expression of tight junction proteins (ZO-1, Occludin, Claudins) and mucins (MUC2), leading to increased intestinal permeability (Tsuzuno et al., 2021

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In addition to NO scavenging by oxyhemoglobin, further studies have demonstrated that erythrocytes can also store and release NO in hypoxic conditions [46]