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The increased mitochondrial oxidative capacity of the skeletal muscle in this study induced by testosterone supplementation may appear of low importance since the mitochondrial oxidative capacity has been shown to be in excess of the maximal capacity for oxygen delivery of the cardiorespiratory system (Boushel and Saltin, 2013)

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The protective nature of A is also evident in vivo as 5XFAD mice [genetic AD mouse model harboring the 5 most prominent familial AD mutations (Oblak et al., 2021)] have significantly better survival profiles than wild type mice in a model of Salmonella typhirium -induced meningitis, and as APP knockout mice fare worse than do wildtypes (Kumar et al., 2016)