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Certain subsets of NKT cells have been shown to play a crucial role in IL-12-mediated anti-tumor immune responses, exerting cytotoxic effects against tumor cells even in the absence of sensitization 25

Tobacco Use by Native North Americans: Sacred Smoke and Silent Killer , ed JC Winter (Univ Oklahoma Press, Norman, OK), pp

Consequently, rather than genuinely improving stress management, nicotine use can exacerbate stress and anxiety over the long term