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To ensure that ARIA is identified should it occur, the appropriate use recommendations for lecanemab suggest health care professionals obtain MRI scans of the brain prior to the 5th, 7th, 14th and 26th infusions, in addition to a baseline scan before starting treatment

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Thus, gut, brain, and kidney signals, a tripartite communication network, are integrated through multiple signaling mechanisms involving vagal signaling, microbiota-derived metabolites, immune-mediated crosstalk, and neuroendocrine regulation