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It can also accelerate degenerative processes and result in early wrinkles, fine lines and age spots

FIGURE 4 Based on the above findings, understanding the regulation of mitochondrial cholesterol trafficking may be of potential relevance in cell death regulation and disease progression

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Specifically, circulating LPS binds to TLR4 on immune cell surfaces, activating the downstream NF-B signaling pathway and promoting the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)