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The five stages are: Stage 0: Cancer hasnt spread beyond the bladder lining Stage 1: Cancer has spread past the lining of the bladder Stage 2: Cancer has spread to the layer of the muscle in the bladder Stage 3: Cancer has spread to tissues surrounding the bladder Stage 4: Cancer has spread to neighboring areas of the bladder The 5-year Jack Jacoub, MD, a medical oncologist and the medical director of MemorialCare Cancer Institute at Orange Coast and Saddleback Medical Centers in California, told Healthline there is a big difference between low risk bladder cancer in its early stages and the high risk version in the latter stages