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140 In the tumor microenvironment, M2 macrophages have been shown to induce angiogenesis, metastasis, and immune escape through the production of various factors such as VEGF, MMP-2, MMP-9 and IL-10

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By contrast, maximum blood concentrations following a 0.1 mg/kg oral dose of rapamycin were greater, with a single oral dose or five consecutive daily doses resulting in mean concentrations of 8.39 ng/ml and 5.49 ng/ml, respectively.[51] On the other hand, despite administering rapamycin via intramuscular injections rather than orally, Paoloni et al