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Conclusions Taken together, our results demonstrate that nicotine-containing ENDS, in the form of e-cigarette vapor, causes the exacerbation of features of COPD in ENaC-overexpressing mice

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Coming at a place in John Ford's canon right after The Grapes of Wrath and The Long Voyage Home , and right before How Green Was My Valley and his war-related hiatus from studio filmmaking, Tobacco Road would seem to fit comfortably in that line of titles - a look at the indignities suffered by an old farmer at the end of the Depression, it almost comes across like a distaff sequel to Grapes - except for the strange matter of its comedy

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