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Impact of nutrient overload on metabolic homeostasis

The results showed that ACTH responses to psychological and physiological stress were significantly blunted in patients with ME/CFS, whereas cortisol responses were relatively preserved or only mildly reduced, suggesting reduced central drive within the stress response system

While more severe forms are not all that common, some research estimates that MCAS could affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]