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Nicotine Replacement Therapies (NRTs) provide nicotine without harmful tobacco smoke toxins and come in various forms like patches, gums, lozenges, inhalers, and nasal sprays

These drugs do not relieve symptoms immediately like nasal and oral decongestants do, but once therapeutic drug levels are achieved, symptoms usually improve, and decongestants may not be necessary

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NMDAR activity is also important in considering the functioning and maintenance of the brain's main inhibitory transmitter -aminobutyric acid (GABA) (82)