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Therefore, it seem reasonable that practical guidelines for the dosage of GSH should be derived from pharmacokinetic studies of sulfur-containing amino acids synchronized with the changes in GSH after the intravenous administration of GSH

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Fluoxetine reduces the mRNA expression of c-Fos through the PI3K/AKT signaling pathway after acute application at concentrations below 1 M, while the treatments with the higher doses (above 5 M), it increases the gene expression of c-Fos via the MAPK/ERK signaling pathway in astrocytes

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