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10.1038/s41467-021-25777-z

Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions

Minimal residual disease assessment in colorectal cancer (MiRDA-C)

In -thalassemia mice, a modest increase in hepcidin expression limited iron overload, reduced the formation of insoluble membrane-bound globin and ROS, and improved anemia