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This activity was predicted in silico to be in part due to the existence of multiple AMP domains on the ApoE molecule, likewise sharing many similarities in mechanism of action such as bacterial membrane disruption similar to other AMPs described earlier (Petruk et al., 2021)

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At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days