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Beyond classic TKIs, the multi-targeted agent anlotinib exerts potent antitumor effects in NSCLC by specifically inducing ferroptosis via the p53/xCT/GPX4 axis (129)

Wang L, Li X, Ying M et al (2023) Amino acid transporters

It is highly addictive and withdrawal symptoms may be severe (but rarely fatal in adults)

Therefore, regulation of intracellular GSH level is a promising strategy to boost the efficacy of antitumor treatment, as the exhaustion of antioxidants is highly desirable to sensitize cancer cells to various therapeutic means, such as chemotherapy, photodynamic therapy (PDT), chemodynamic therapy (CDT), and radiotherapy