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Our efforts have included in vitro studies, animal studies, pharmacokinetic analyses, and clinical trials

Some of these functions are significantly reduced only after adolescence, such as biosynthesis and degradation of polysaccharides, pentose phosphate pathway and TCA cycle. Therefore, also at a functional level, adolescence seems to represent a stage of transition towards an adult microbiome, where some functions have attained adult-like relative abundances whereas others are still present at the levels seen in young children

From reconstitution to injection frequency, getting the dosage right is the single most critical factor for both safety and efficacy

Nature 417, 447452