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Specific protein 1 (SP1)-mediated upregulation of PRDX6 expression also prevented iron overload by regulating iron metabolism, restoring SLC7A11 activity and GSH activity, and further promoting the increase in GPX4 expression to prevent ferroptosis-associated DN [238]

J Endocrinol 2015

Consistent with the in vivo experimental results, these observations implied that Acsl4 knockout alleviated CaOX-induced mitochondrial dysfunction and reduced lipid peroxidation, thereby decreasing ferroptosis in MTECs

Following ingestion, quercetin is rapidly absorbed and its levels in blood peak at approximately in 30 min [63] before it is metabolized by glucuronidation and sulfation by the UGT and ST, respectively